ea0090p478 | Thyroid | ECE2023
Zheng Wei
, Wu Ruixin
, Li Ning
, Wang Xuan
, Wang Shen
, Tan Jian
Background: The study aimed to establish a mouse model of Graves disease (GD) with Graves ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...